Health Care News | Medical Research

How Has COVID-19 Reshaped the World of Drug Discovery?

We’re past the five-year mark since the onset of COVID-19… how did the pandemic (and the subsequent vaccine roll out) reshape the world of drug discovery?

DocWire News spoke to Thomas Swalla, CEO of Dotmatics, which enables researchers to work faster on scientific discoveries. Swalla provided insight into this topic by describing how COVID-19 shattered traditional drug development timelines (the success of accelerated vaccine approvals), and now AI is reshaping drug discovery even further—helping researchers work at an unprecedented pace.

Conservative Management Versus Dialysis for Patients With Advanced CKD

Victoria SochaNKF Spring Clinical Meetings 2025 | April 3, 2025

A study compared the impact of conservative management of CKD vs transition to dialysis on risk for cognitive dysfunction.

FDA Grants Orphan Drug Designation to Bexobrutideg for Waldenström Macroglobulinemia

Melissa BadamoHematology | April 3, 2025

Bexobrutideg, an orally bioavailable, brain-penetrant BTK degrader, is being evaluated in a phase 1a/b study.

Evaluating HER2-Low in Metastatic Breast Cancer: Cytological Insights Into Proliferation and Survival

Brianna GrahamHER2 Breast Cancer | April 3, 2025

Cytology provides new insights into HER2-low metastatic breast cancer, revealing proliferative features and survival trends.

Effect of KidneyIntelX DKD Risk Predictions on SGLT2i Prescription Rates

Charlotte RobinsonNKF Spring Clinical Meetings 2025 | April 2, 2025

Researchers assessed how prescription rates of SGLT2i were affected when DKD risk was predicted by a KidneyIntelX test.

GLP1 RA Superior to Bariatric Surgery for Improving Cardiovascular Outcomes in People With Obesity

Rob DillardACC.25 | April 2, 2025

GLP1 RA provides a notably superior weight loss option for people with obesity compared with bariatric surgery.

Study Finds Rising Trends in Obesity-Related Cardiac Tachyarrhythmia Deaths

Rob DillardACC.25 | April 2, 2025

A novel study shows a rising trend in cardiac tachyarrhythmia deaths related to obesity.

An Alarming Increase in Obesity Among Black Children During the COVID-19 Pandemic

Rob DillardACC.25 | April 2, 2025

A new study finds a striking increase in obesity prevalence among Black children during the COVID-19 pandemic.

Telehealth Parity Laws Prevent Heart Failure Hospitalizations

Rob DillardACC.25 | April 2, 2025

Telehealth parity laws notably reduce hospitalization in acute decompensated heart failure.

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GI Oncology Now is the leading medical news resource for practicing oncologists and health care providers treating gastrointestinal malignancies, offering the latest study data and research breakthroughs related to colorectal, gastric, liver, pancreatic, and esophageal cancers.

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Nephrology Times delivers the latest news in nephrological treatments and technologies, curating content from clinical trials, conference highlights, and perspectives from key opinion leaders, with the goal of better informing care decisions and improving patient outcomes.

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Suvemcitug Combination Shows Promise in MSS/pMMR Colorectal Cancer

Emily MenendezColorectal Cancer | March 17, 2025

Suvemcitug, envafolimab, and FOLFIRI may serve as a new second-line treatment option for cold tumors.

Genetic Resistance to KRASG12C Inhibitors in CRC and PDAC

Emily MenendezPancreatic Cancer | March 17, 2025

KRASG12C inhibitors can have reduced efficacy in patients with alterations in KRAS, EGFR, and other genes.

Complete Response to Immunotherapy in HCC: Insights From IMbrave150

Emily MenendezLiver Cancer | March 14, 2025

Complete responders with HCC have prolonged survival and durable disease control even after therapy has been discontinued.

177Lu-edotreotide Improves PFS, OS Over Everolimus for SSTR-Positive GEP-NETs

Emily MenendezGEP-NETs | March 12, 2025

The primary objective of median PFS was significantly longer for patients treated with 177Lu-edotreotide.

MATTERHORN: Durvalumab Plus FLOT Improves EFS and pCR in Gastric, GEJ Cancers

Emily MenendezGastroesophageal Cancer | March 12, 2025

The safety profile of the combination was consistent with known profiles, and no new safety findings were observed.

Risk for Choledocholithiasis Higher in Older Adult Patients With Cholangiocarcinoma

Emily MenendezBile Duct Cancer | March 11, 2025

Older patients in their 70s with extrahepatic CCA have a higher rate of choledocholithiasis.

The Latest From Heme Today

FDA Grants Orphan Drug Designation to Bexobrutideg for Waldenström Macroglobulinemia

Melissa BadamoHematology | April 3, 2025

Bexobrutideg, an orally bioavailable, brain-penetrant BTK degrader, is being evaluated in a phase 1a/b study.

FDA Grants Orphan Drug Designation for MDS to Investigational CLEVER-1-Targeting Immunotherapy

Andrew MorenoMDS | April 2, 2025

The agent recalibrates the immune system to attack tumors and increases cancer susceptibility to standard of care therapy.

Investigational T-Cell Immunotherapy Superior to Standard HSCT in Rate of Survival Plus GvHD Freedom

Andrew MorenoMDS | March 31, 2025

A phase 3 study comparing the treatments in multiple hematologic malignancies also saw greater overall survival at one year.

Pushing the Limits for More Treatment Options for Von Willebrand Disease

Melissa Badamovon Willebrand Disease | March 27, 2025

As the most common bleeding disorder, von Willebrand disease is found in up to 1% of the United States population.

$Novel CAR T-Cell Therapy for Relapsed Refractory DLBCL Receives FDA Fast Track Designation$

Novel CAR T-Cell Therapy for Relapsed Refractory DLBCL Receives FDA Fast Track Designation

Andrew MorenoHematology | March 26, 2025

Azercabtagene zapreleucel is an allogeneic CD-19-targeting therapy combining lymphodepletion chemotherapy with interleukin-2.

Injectable Rusfertide Shows Promise for Erythrocytosis Control in Phlebotomy-Dependent PV

Andrew MorenoPolycythemia Vera | March 25, 2025

The hepcidin mimetic increased hematocrit control and reduced both phlebotomy need and symptoms in a phase 2 trial.

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