Esophageal Cancer
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Pembrolizumab previously received accelerated approval for this indication in 2021 based on interim results from KEYNOTE-811.
The safety profile of the combination was consistent with known profiles, and no new safety findings were observed.
Dr. Cytryn shares insights on the implications of recent data from the DESTINY-Gastric04 and MATTERHORN trials.
The approval is based on positive results from the phase III RATIONALE-306 study.
Patients with refractory UGI cancers who participated in phase I trials saw benefits in late-line settings.
Dr. Cytryn summarizes a trial in progress investigating a novel immunotherapy combination for gastroesophageal adenocarcinoma
The panel discusses considerations around treating peritoneal gastric cancer, including the role of HIPEC.
In part three of their discussion, the panel explores the role of ADCs in treating gastric and esophageal cancers.
The panelists discuss the impact of biomarkers on personalized gastric cancer care, including ctDNA, claudin 18.2, and PD-L1.
An expert panel of GI oncologists debates recent advancements in biomarker-driven strategies for GI cancer care.
Dr. Cytryn reviews the FDA approval of tislelizumab and shares thoughts on its clinical impact.
Tislelizumab is a monoclonal antibody with a high affinity and binding specificity against programmed cell death protein 1.
The FDA has approved nivo for subcutaneous injection for all solid tumors for which nivo is indicated as a monotherapy.
Dr. Cytryn provides insights on the FDA approval of zolbetuximab and how it will impact clinical practice.
Both of the double-blind, multicenter trials evaluated the major efficacy outcomes of PFS and OS.
The phase III study found that regorafenib improved overall survival in patients with refractory advanced gastric cancer.
Tislelizumab shows significant survival benefits in first-line treatment for gastric and esophageal cancers.
FDA approval of the first and only CLDN18.2-targeted treatment follows two successful phase III clinical trials.
For postoperative morbidity and mortality, surgery alone had the highest probability rate.
Dr. Weinberg provides a recap of all of the GI oncology data of practice-changing potential presented at ESMO 2024.
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