Christopher Lieu, MD, University of Colorado Medicine, lists and describes his picks for the most impactful studies from the 2025 ASCO Annual Meeting, including DESTINY-Gastric04, CHALLENGE, MATTERHORN, BREAKWATER, and ATOMIC.
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Dr. Perez breaks down her study that investigated the use of ramucirumab and somatostatin in patients with advanced NETs.
The ACCORD trial evaluated the efficacy of combined IO and radiotherapy in patients with resectable biliary tract cancers.
Dr. Chakrabarti highlights 100% response with PD-1 blockade in dMMR rectal cancer and new chemoimmunotherapy for anal cancer.
Dr. Chakrabarti shares BREAKWATER, CheckMate 8HW, and CHALLENGE results improving metastatic colorectal cancer outcomes.
Dr. Chakrabarti highlights ATOMIC as the new standard for stage III dMMR colon cancer and compares it to the NICHE approach.
KRAS mutations drive GI cancers, but new inhibitors, vaccines, and combinations are advancing efforts to target them.
Precision oncology is advancing in pancreatic cancer, but testing gaps and tough biology limit access to targeted treatments.
Irinotecan with ramucirumab did not provide a significant OS advantage over irinotecan monotherapy.
Dr. Goff shares how she chooses between atezo/bev and doublet IO regimens like durva/trem or ipi/nivo for patients with aHCC.
Dr. Kopetz explains how BREAKWATER aligns with Project FrontRunner to support accelerated approval in BRAF V600E-mutated CRC.
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Editorial Advisory Board
Christopher Lieu, MDEditor | Co-Director of Gastrointestinal Medical Oncology at University of Colorado Medicine
Benjamin Weinberg, MD, FACPEditor | Associate Professor of Medicine at Lombardi Comprehensive Cancer Center
Zev Wainberg, MD, MScEditor | Co-Director of Gastrointestinal Oncology at the University of California, Los Angeles
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