The phase 2 randomized trial included patients with amyloid-confirmed mild cognitive impairment or early Alzheimer disease. Researchers assessed the molecular underpinnings that may increase the risk of Alzheimer’s disease following TBI. Researchers have developed a novel therapy that selectively removes aggregated tau proteins, which are associated with AD. Dr. Alva discusses a study that evaluated the safety of pimavanserin in frail elderly patients with NDD. Hormone therapy was associated with a 19% lower relative risk in Black women aged 65 to 74 years. Among patients with T2DM, the risk of dementia and Alzheimer disease is lower in those treated with metformin. A 5-minute assessment was found to improve the diagnosis of mild cognitive impairment and dementia. People who inherit a history of Alzheimer disease from their mother's side have a higher risk of developing AD. Midpoint of sleep is associated with multiple measures of sleep quality and could be a biomarker for AD risk. Xanomeline-trospium chloride is effective and well tolerated in patients with schizophrenia experiencing acute psychosis. Individuals who suffer a stroke have a significantly increased risk of developing dementia. Former professional American football players who have medical and mental health conditions are at higher risk of CTE. A novel blood test could be used to effectively screen for Alzheimer disease, even before the onset of symptoms. Rafael Carbunaru talks about a recently approved software that benefits patients with Parkinson disease or essential tremor. Treatment with brexpiprazole led to a significant improvement in agitation for patients with dementia due to AD. Patients with type 1 diabetes who exhibit the presence of albuminuria have an escalated pace of brain atrophy. Duke Han, PhD, and Laura Fenton, a doctoral student, describe a study that shows the impact of cognitive impairment. Findings from a recent study suggest that racial disparities exist in the presentation of frontotemporal dementia. Individuals who are exposed to higher levels of air pollution over a long-term duration have a greater risk of dementia. Playing American football is linked with a higher risk of developing Parkinson disease.