A study has uncovered a novel method to enhance immunotherapy for melanoma by targeting a protein known as MARCO. Dr. John Fruehauf details how novel therapies have improved the landscape of metastatic melanoma care. The main features of intestinal inflammation are reproduced as a biomarker for response to immune checkpoint inhibition. New research has uncovered a combination therapy that shows promising results in melanoma and breast cancer models. A recent study shows that macrophages can be used to predict whether or not a melanoma patient will respond to chemotherapy. A recent study found a connection between total serum calcium levels and developing melanoma. Dr. John Fruehauf provided an in-depth overview of treatments for metastatic melanoma. The primary outcomes of the study were melanoma-related deaths and nonmelanoma-related deaths. TPC2 and Rab7a interaction may be responsible for melanoma proliferation. Remote analysis of cancerous-looking skin growths yields the same level of accuracy as in-person analysis. Seventy-two percent of tumor specimens contained histologically defined LAs. The analysis included the CheckMate trials that involved ICI treatment-naive unresected/metastatic melanoma. Dr. John Fruehauf, Evolent, talks about a new standard of care in the treatment of stage III melanoma. The combo's use for conjunctival melanoma demonstrates the combinations high efficacy in treating complex disease. A novel method uses tumor-specific profiling to detect antibodies which are unique to early-stage melanoma. The combination therapy of sotiga with pembrolizumab is effective at treating patients with metastatic melanoma. Polygenic risk scores may serve as a viable tool to stratify patients based on their risk of invasive melanoma. Several studies have uncovered how immunotherapies work in concert to improve outcomes in patients with melanoma. A factor secreted by tumor cells is responsible for the resistance of melanoma to treatment. One year of immunotherapy is optimal for treating patients with advanced melanoma.