Gender disparities persist in clinical trials related to atrial fibrillation (AF) management. The newly approve products include four new sizes. Our editors provide cardiology professionals with practice-enhancing clinical data, as featured at ACC.25. Sudden cardiac death increases amid lower daily temperatures. Acoramidis therapy significantly increases serum transthyretin in people with ATTR-CM compared with tafamidis. Patients with single ventricle heart disease commonly have mental health diagnoses. Our editors, along with the CardioNerds, bring you insightful research, KOL videos from ACC.25, focused on ATTR-CM. Acoramidis therapy induces a significant increase in serum transthyretin, which is typically lower in ATTRv-CM. The CardioNerds, along with colleagues detail a case involving a patient with newly diagnosed hypertriglyceridemia. The CardioNerds and expert faculty discuss a complicated case of ventricular tachycardia. The CardioNerds and Dr. Robert Mentz discuss the important steps in treating HF with mineralocorticoid antagonists. Drs. Akiva Rosenzveig and Jenna Skowronski are joined by Dr. Randall Starling to discuss logical steps in HF management. The CardioNerds in tandem with Dr. Clyde Yancy analyze a case of an 80-year-old man with heart failure. The CardioNerds and expert faculty Dr. Shelley Zieroth analyze a patient's heart failure classification. The CardioNerds and expert faculty Dr. Mark Drazner assess a woman's heart failure status. The CardioNerds and Dr. Mark Drazner discuss the right heart failure device placement with an elderly patient. The CardioNerds and expert faculty Dr. Biykem Bozkurt discuss a 63-year-old patient with hypertension and T2D. The CardioNerds and colleagues review the differential diagnosis for peripartum cardiomyopathy. The CardioNerds discuss a case involving a patient who presented with stress cardiomyopathy leading to cardiogenic shock. Our editors supply late-breaking clinical content and KOL video interviews from AHA 2024.