Breast Cancer

De-Escalation of Neoadjuvant Chemoimmunotherapy May Be Feasible Option

Leah LawrenceTriple-Negative Breast Cancer | April 9, 2025

Shorter chemoimmunotherapy shows promise in early TNBC, with higher pCR in PD-L1+ or TIL-high patients, Neo-N trial finds.

Study Shows No Clinical Benefit Observed With Atezolizumab as Adjunctive Therapy for Triple Negative Breast Cancer

Yvette C. TerrieTriple-Negative Breast Cancer | April 8, 2025

Adding atezolizumab to chemotherapy did not result in clinical benefit in patients with triple-negative breast cancer.

Imlunestrant is a Viable Second-Line Option for Advanced HR-Positive, HER2-Negative Breast Cancer

Leah LawrenceHR Breast Cancer | April 7, 2025

Imlunestrant with or without abemaciclib improved PFS in ER+/HER2- advanced breast cancer post-endocrine therapy.

Study Shows That Black Patients With Metastatic Breast Cancer Tend to Experience Higher Mortality Rates Than White Patients

Yvette C. TerrieBreast Cancer News | April 6, 2025

Study finds somatic differences and lower PI3K inhibitor use in Black vs White patients with metastatic breast cancer.

PENELOPE-B Final Analysis: Palbociclib Shows No Survival Benefit in High-Risk HR+/HER2- Breast Cancer

Brandon TwyfordHR Breast Cancer | April 5, 2025

Final results from the PENELOPE-B trial show palbociclib did not improve survival in high-risk HR+/HER2– breast cancer.

EU Approves Enhertu for HR-Positive, HER2-Low, HER2-Ultralow Metastatic Breast Cancer Following Endocrine Therapy

Brandon TwyfordHER2 Breast Cancer | April 4, 2025

Enhertu approved in the EU for HR+, HER2-low, -ultralow metastatic breast cancer, showing PFS benefit over chemotherapy.

Interim SERENA-6 Data: Camizestrant Significantly Improves PFS in First-Line HR+/HER2- Advanced Breast Cancer With ESR1 Mutations

Yvette C. TerrieHR Breast Cancer | April 4, 2025

Camizestrant plus CDK4/6 inhibition significantly improved PFS in HR+/HER2– advanced breast cancer with ESR1 mutations.

Evaluating HER2-Low in Metastatic Breast Cancer: Cytological Insights Into Proliferation and Survival

Brianna GrahamHER2 Breast Cancer | April 3, 2025

Cytology provides new insights into HER2-low metastatic breast cancer, revealing proliferative features and survival trends.

Improving HER2-Low Diagnosis in Metastatic Breast Cancer: Validating a Scoring System to Enhance Pathologist Precision

Brianna GrahamHER2 Breast Cancer | April 2, 2025

A new study validates a HER2-low–focused scoring system to improve diagnostic accuracy in metastatic breast cancer.

Prognostic Impact of HER2-Low Expression in Early Breast Cancer Highlighted in Patients With Node Metastasis

Brandon TwyfordHER2 Breast Cancer | April 2, 2025

Study finds HER2-low vs HER2-zero breast cancer similar overall, but HER2-low shows better RFS if node-positive.

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Section Editor

Dr. Sadie Dobrozsi, EvolentHematologist/oncologist and Medical Director, Evolent