The study used SEER data of nearly 20,000 cases. People diagnosed with metastatic breast cancer have a notably increased risk of developing heart disease. The CDK4/6 inhibitor showed meaningful improvement in HR+, HER+ disease. New research suggests ICI therapy improves efficacy outcomes in early-stage breast cancer over adjuvant therapy. The Breast Cancer Index assists in decision-making regarding adjuvant endocrine therapy for hormone receptor-positive BC. Dr. Mik Rinne discusses a study on the efficacy of the CDK2 inhibitor BLU-222 in patients with HR+/HER2- breast cancer. Dr. Margaret Gatti-Mays details the treatment options for BC patients in the hormone receptor-positive metastatic setting. The Oncology Brothers spoke with Dr. Margaret Gatti-Mays, who provided invaluable insights on hormone receptor-positive BC. Patients ≥70 years of age were more likely to have a reduction in their palbociclib dosage. The FDA recently approved a new combination therapy for the treatment of HR-positive, HER2-negative breast cancer. The Oncology Brothers talk with Paolo Tarantino, MD, about the TROPiCS-02 study presented at SABCS. Results from the 21-gene Breast Recurrence Score commercial assay were successful predictors for cancer-specific mortality. The Oncology Brothers were live at ASCO 2023 to discuss findings from the TROPiCS-02 study. Sacituzumab govitecan wasn't cost-effective in HR+/HER2- metastatic breast cancer for third-party payers in the US.