Rob Dillard

DocwireNews

A novel predictive digital pathology biomarker of immune checkpoint blockers (ICB) demonstrates high predictive response power in first-line head and neck cancers (HNC), according to a study presented at the European Society for Medical Oncology (ESMO) Congress 2024.
Investigators analyzed 26 cases of patients with metastatic HNC treated with first-line PD-1 inhibitors, all with CPS&gt;1%. They then utilized their ENLIGHT-DP pipeline to generate, in a blinded manner, individual response scores to PD-1 inhibition for tissue sample slides. They noted that ENLIGHT-DP has two main steps: prediction of mRNA expression directly from an H&amp;E slide using DeepPT, their digital-pathology based algorithm; and use of these values as input to ENLIGHT, their transcriptome-based precision oncology platform.
The findings showed that the ENLIGHT-DP score had an overall response rate of ROC AUC ¼ 0.65. The researchers noted that using a predefined threshold for binary classification of response derived from independent data, six of eight patients that were predicted to respond by ENLIGHT-DP responded (75% PPV, 43% sensitivity, Odds Ratio of 3.75). In comparison, stratification by CPS exhibits no predictive power (PPV of 50% and 58%, respectively, for CPS &gt;20% and CPS 1-19%, and AUC of 0.46 for CPS as a continuous score), the researchers noted.
&#8220;ENLIGHT-DP demonstrates high predictive power for response to ICB in first-line HNC, outperforming the commonly used CPS marker. Importantly, our approach does not require training on prior treatment outcomes, and can therefore be generalized to drugs for which such data is unavailable or scarce,&#8221; the researchers concluded.
Reference
Bentebibel SE, McGrail D, Wahab R. Clinical and biomarker analyses of intratumoral CD40 agonist sotigalimab in combination with pembrolizumab in metastatic melanoma: A phase I/II trial. Abstract #71MO. Presented at the European Society for Medical Oncology Congress 2024; September 13-17, 2024; Barcelona, Spain.

Emily Menendez

KEYNOTE-177 5-Year Follow-Up Shows Durability of Pembrolizumab for mCRC

Colorectal Cancer

Laura Litwin

Can Epigenetics Determine the Best Diet for Lung Health?

Lung Cancer

Changes in Maximum Daily Atrial Fibrillation Duration Linked With Poor Outcomes in Patients With Cardiac Implantable Electronic Devices

AHA 2024

Latest News

Assessing a Novel Predictive Marker of Immune Checkpoint Response in Head and Neck Cancer

Head and Neck Cancer

A novel predictive digital pathology biomarker demonstrates high predictive response in head and neck cancer.

About Us

Editorial Policy

Advertising

eNewsletters

Contribute

Contact Us

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

Mesothelioma

Non-Small Cell Lung Cancer

Small Cell Lung Cancer

Squamous Cell Lung Carcinoma

Lung Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Oncology

Sleep

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

The Oncology Brothers

Rheumatology Rounds With Dr. Maheswaranathan

Healthcare Unfiltered

The Fellow on Call

Partners

Hurricanes & Health Care

Career Center

Expert Interviews

Subscribe