Certain athletes with CVD abnormalities may be able to safely participate in competitive sports. Dr. Anne Marie Morse discusses the troubling connection between sleep disorders and dementia. Thomas Ruggia, CEO of Samsara Vision, talks about a novel implantation device for age-related macular degeneration. The CardioNerds and Dr. Robert Mentz discuss the important steps in treating HF with mineralocorticoid antagonists. Transient ischemic attack (TIA) is associated with long-term cognitive decline. Dr. J.Quentin Clemens talks about the current treatment landscape around interstitial cystitis. Larry Lipshultz, MD, discusses the concurrent use of testosterone replacement therapy, especially as it pertains to couples. Researchers found two effective treatments for metaplastic breast cancer. Patient outreach with bulk ordering may result in higher lipid screening uptake than usual care. The CardioNerds in tandem with Dr. Clyde Yancy analyze a case of an 80-year-old man with heart failure. Supine blood pressure is correlated with a higher risk of adverse CVD risk. New research has uncovered a combination therapy that shows promising results in melanoma and breast cancer models. Aliya Omer, AstraZeneca, talks about data that backs the efficacy of olaparib in treating high-risk early breast cancer. The FDA approved esketamine nasal spray for the treatment of adults living with major depressive disorder. The FDA recently announced a first time proposed rule which would require the tobacco industry to lower nicotine levels. In patients with high-risk HER2-psoitive breast cancer, adjuvant trastuzumab emtansine reduces the long-term risk of death. A new study assessed the link between the cardiometabolic index and the risk of SUI in women. A recent study shows that macrophages can be used to predict whether or not a melanoma patient will respond to chemotherapy. A study shows that humans, mice exposed to long-wavelength red light have lower rates of blood clots that cause stroke. Researchers developed an artificial intelligence algorithm that may improve the diagnosis of REM sleep behavior disorder.