Interim APPLAUSE-IgAN data showed that iptacopan was superior to placebo at reducing proteinuria at nine months. A MAMS platform trial will examine use of antiproteinuric and immunomodulatory therapies in glomerular diseases. Zigakibart for treatment of IgA nephropathy (IgAN) was well tolerated, reduced proteinuria, and stabilized eGFR at 76 weeks. A study examined the clinical relevance of urinary mRNA levels in patients with IgA nephropathy (IgAN). A study examined whether COVID-19 independently affects the subsequent trajectory of kidney function in patients with IgAN. A study analyzed the fecal microbiome of patients with IgA nephropathy, focusing on their immune response to microbiota. Researchers examined the role of urinary sodium excretion and the progression of immunoglobulin A nephropathy (IgAN). Could adding serum C3 and C4 levels to existing predictive models for IgA nephropathy (IgAN) improve their accuracy? Jonathan Barratt discussed advances in IgA nephropathy treatment with Joel Topf at ASN Kidney Week 2024. A novel endothelin receptor type A selective antagonist showed a meaningful reduction in proteinuria in patients with IgAN. Treatment of IgA nephropathy with felzartamab led to sustained proteinuria reduction and reduced eGFR decline. Jonathan Barratt discussed his research on the anti-APRIL antibody sibeprenlimab in the treatment of IgA nephropathy. BAFF and APRIL inhibitor atacicept reduced UPCR, hematuria, and Gd-IgA1 and stabilized eGFR in patients with IgAN. IgAN was a hot topic at ASN Kidney Week and was the focus of an exhibitor spotlight on pathogenesis and the role of APRIL. Could the systemic inflammatory response index (SIRI) be a useful measure of renal prognosis in IgA nephropathy (IgAN)? Diffuse magnetic imaging resonance shows promise for evaluating clinical and pathological changes in patients with IgAN. Surveyed physicians indicated that IgAN patients were referred to them late and not all potential cases had a timely biopsy. C3 plays a key role in the formation of Gd-IgA1-containing IC with a nephritogenic capacity for IgAN. Clinical improvement does not always reflect pathology, so renal biopsy may be needed to determine IgAN treatment efficacy. Even when levels are below the current KDIGO threshold, proteinuria in IgAN indicates a risk of kidney failure.