Association of Urinary Sodium Excretion With IgAN Progression

Guizhen Yu and colleagues sought to determine the role of urinary sodium excretion and the progression of immunoglobulin A nephropathy (IgAN). They reported their findings in the American Journal of Nephrology.

Their study included 596 patients with IgAN whose urinary sodium excretion was measured at kidney biopsy. The researchers used Cox proportional hazards models and restricted cubic splines to evaluate the association between urinary sodium excretion and kidney disease progression events (50% eGFR decline or development of kidney failure).

During a mean follow-up period of 58.9 months, 75 (12.6%) participants reached the composite kidney disease progression events. The risk of these events was greater among participants with higher urinary sodium excretion. After the researchers adjusted for traditional risk factors, a higher level of log-transformed urinary sodium excretion was associated with kidney disease progression events in the IgAN patients (HR, 2.1; 95% CI, 1.4-3.2). Hazard ratios were 1.9 (95% CI, 1.0-3.4) for the second tertile and 2.1 (95% CI, 1.1-3.9) for the third tertile, in reference to the first tertile of urinary sodium excretion.

In conclusion, higher levels of urinary sodium excretion were associated with kidney disease progression events in individuals with IgAN independent of clinical and biopsy characteristics.

Source: American Journal of Nephrology