Study Finds a Significant Correlation Between Amyloidosis and Atrial Fibrillation

People with amyloidosis have a significantly higher prevalence of atrial fibrillation, according to a study presented at AHA 2024.

In this analytical cross-sectional study, researchers assessed a total of 147,015,073 admissions of patients aged 18 years and above. They employed statistical and univariate logistic regression models to analyze the prevalence rates and odds ratios (OR) The researchers noted that multivariate logistic regression modeling was then used to adjust various potential confounders, including age, gender, race, income, hypertension, diabetes, stage 3 or above chronic kidney disease (CKD), Charlson comorbidity index, and hospital-related factors.

The findings showed that the five-year prevalence of AF was 36.73% and 15.42% in admissions with and without AM, respectively. The results of univariate logistic regression analysis showed a markedly elevated OR for AF of 3.18 (95%CI: 3.102 – 3.267, P<0.000) in admissions with amyloidosis compared to those without.

The researchers concluded that the findings “indicate the need for a comprehensive workup of suspected atrial fibrillation in amyloidosis patients. Further research should investigate the mechanisms behind this association and potential prevention.”

Reference

Khatiwada A, Tran V, Nguyen D, et al. Prevalence of Atrial Fibrillation in Amyloidosis and Their Association: A 5-Year Nationwide Analytical Cross-Sectional Study. Abstract #Su2089. Presented at the American Heart Association Scientific Sessions 2024; November 16-18, Chicago, Illinois.