Renal Dysfunction is a Predictor of Adverse Cardiovascular Outcomes in Patients With Diabetes

Renal dysfunction, especially chronic kidney disease (CKD), increases the risk of major adverse cardiovascular events (MACEs) in patients with type 2 diabetes mellitus (T2DM), according to a study published in Acta Cardiologica.

Researchers assessed renal function and outcomes in 505 diabetic patients undergoing percutaneous coronary intervention  (PCI). The population of interest were stratified using glomerular filtration rate (GFR). Logistic regression and receiver operating characteristic (ROC) analysis were used to analyze the associations and predictive capabilities.

According to the results, there were notable differences regarding age, creatinine levels, and number of culprit vessels between diabetics with and without CKD. The researchers found that severe CKD was associated with higher odds of mortality at one month (OR: 15.694, p value <.001), one-month MACE (OR: 7.734, p value <.001), and TVD (OR: 3.740, p value <.001). Patients with severe CKD also had significantly higher odds of six-months mortality (OR: 12.192, p value <.001) and 6-months MACE (OR: 3.848, p value: .001). Moreover, the researchers noted that GFR demonstrated notable predictive accuracy for mortality at one- and six-months follow-up (AUC: 0.77 and 0.71, respectively).

“Renal dysfunction, particularly severe CKD, significantly elevates risks of MACE, mortality, and TVD. Strategies to optimize renal function and tailor cardiovascular management could mitigate adverse outcomes in this high-risk population,” the researchers concluded.