Kaitlyn D’Onofrio

DocwireNews

A new study observed that children born after a <a href="https://www.docwirenews.com/docwire-pick/lmaternal-hormonal-birth-control/">frozen embryo transfer</a> had a “small but statistically significant increased risk” of developing childhood <a href="https://www.docwirenews.com/docwire-pick/hem-onc-picks/study-compares-single-vs-multifraction-radiotherapy-for-spinal-canal-compression-from-metastatic-cancer/">cancer</a>.
“Children born after use of fertility treatment have higher risks of adverse perinatal outcomes, including prematurity, low birth weight, and congenital malformations; however, the long-term health consequences have been studied less frequently,” wrote the study authors. “It has been suggested that the use of fertility treatment increases the risk of cancer in children, possibly through epigenetic changes brought on by the use of fertility drugs, [assisted reproductive technology] ART, or both,6 which has been supported by the finding of epigenetic changes in human oocytes, embryos, cord blood, and placentas. In addition, an unexpectedly large proportion of children conceived after the use of fertility treatment are born with rare imprinting disorders due to epigenetic changes.”
This was a retrospective cohort study evaluating Danish population-based registry data and the Danish Infertility Cohort that included 1,085,172 children born in Denmark between Jan. 1, 1996, and Dec. 31, 2012; these data were linked with parental information. During follow-up (1996 through 2015), 2,217 children received a cancer diagnosis.
Exposures were maternal fertility treatment during the index pregnancy; treatments included fertility drugs (clomiphene [n = 33,835], gonadotropins [n = 57,136], gonadotropin-releasing hormone analogs [n = 38,653], human chorionic gonadotropin [n = 68,181], progesterone [n = 41,628], and estrogen [n = 16,948]) and assisted reproductive technology (in vitro fertilization [n = 19,448], intracytoplasmic sperm injection [n = 13,417], and frozen embryo transfer [n = 3,356]). Children born to women who received fertility treatment were compared to children born to fertile women (n = 910,291). The primary outcome measure was hazard ratios (HRs) and incidence rate (IR) differences for childhood cancer.
Final analysis included 12.2 million person-years of follow-up (mean, 11.3 years). Children born to fertile women had an IR of childhood cancer of 17.5 per 100,000, compared to 44.4 per 100,000 for children born after frozen embryo transfer. Children born to mothers who underwent frozen embryo transfer, compared to those born to fertile women, had an increased risk of childhood cancer (14 cancer cases; HR=2.43; 95% confidence interval [CI], 1.44-4.11; IR difference, 26.9 per 100,000; 95% CI, 2.8-51.0). This was primarily attributed to an increased risk of leukemia, which accounted for five cancer cases (IR, 14.4 per 100,000; HR=2.87; 95% CI, 1.19-6.93; IR difference 10.1 per 100,000; 95% CI, –4.0-24.2), as well as sympathetic nervous system tumors (&lt;5 cancer cases; HR=7.82; 95% CI, 2.47-24.70). Cancer risks were not statistically significant in the other fertility treatments.
The results of the study appeared in <a href="https://jamanetwork.com/journals/jama/fullarticle/2757228?guestAccessKey=d0ac6271-6e75-4fe0-babd-c035de1c4a4e&amp;utm_source=For_The_Media&amp;utm_medium=referral&amp;utm_campaign=ftm_links&amp;utm_content=tfl&amp;utm_term=121019">JAMA</a>.

Dr. Hemal Gada

Rob Dillard

Dr. Hemal Gada: Evolut TAVR Demonstrates 'Favorable' Clinical Outcomes

Interventional Cardiology

Heart Failure Patients Vaccinated Against COVID-19 Live Longer

Heart Failure

Many Patients With Ulcerative Colitis Suffer From This 'Often Neglected' Symptom

DDW 2024

Latest News

Children Conceived with Fertility Treatment at Slight Increased Risk for Cancer

Oncology

A new study observed that children born after a frozen embryo transfer had a “small but statistically significant increased risk” of developing childhood cancer. ...

About Us

Editorial Policy

Advertising

eNewsletters

Contribute

Contact Us

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

Mesothelioma

Non-Small Cell Lung Cancer

Small Cell Lung Cancer

Squamous Cell Lung Carcinoma

Lung Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Hypertension

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Diabetes

Neurology

Rheumatology

Gastroenterology

Pulmonology

Ophthalmology

Infectious Diseases

— HIV

Health and Wellness

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Fellow on Call

Healthcare Unfiltered

The Oncology Brothers

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Career Center

Expert Interviews

Subscribe