The systemic inflammatory response index (SIRI) is an easily accessible measure of inflammation and disease prognosis, but its usefulness for predicting outcomes in IgA nephropathy (IgAN) was unknown. Therefore, Dandan Yang and colleagues conducted a retrospective study to fill the knowledge gap. Their findings were published by International Urology and Nephrology.
The investigation included 981 patients with biopsy-confirmed IgAN from West China Hospital of Sichuan University between 2008 and 2019. Participants were divided into two groups based on the optimal cutoff value of the SIRI. There were 312 patients in the low SIRI group (≤0.63) and 669 in the high SIRI group (>0.63).
The researchers assessed clinical characteristics at renal biopsy and analyzed the relationship between SIRI and the combined endpoint. They also conducted analyses using the Cox proportional hazard model and Kaplan‒Meier curve to evaluate the renal prognosis of IgAN.
During a median follow-up of 56.7 months (36.8-80.4 months), 122 (12.4%) participants reached the combined endpoint. Additional analysis found that a higher SIRI value was significantly associated with the risk of reaching the composite endpoint (HR, 1.62; 95% CI, 1.02-2.56; P=.041).
In summary, high SIRI was found to be a significant independent risk factor for renal disease progression in patients with IgAN.
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