Association Between Gout and Kidney Stones

The association between gout and kidney stones is unclear, so Shengkai Jin and colleagues investigated their relationship using data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). They also conducted Mendelian randomization (MR) analysis of data from the Genome-Wide Association Studies (GWAS) database to explore potential causality.

The NHANES analysis, which included 28,742 participants, showed that gout status was associated with a higher risk of kidney stones (odds ratio [OR], 1.45; 95% CI, 1.243-1.692; P<.001). The MR analysis uncovered a causal relationship between gout status and the risk of developing kidney stones (OR, 1.047; 95% CI, 1.011-1.085; P=.009).

Although the findings suggest that there may be an association between gout status and kidney stone risk, the authors caution that additional large-sample studies and adequate follow-up are needed.

Source: Frontiers in Genetics