Recognizing and managing concurrent gout and CKD is important for improving outcomes but can be difficult. There are few data available on the associations between serum urate levels and the risk of recurrent gout. A study found notable lipid profile changes in hyperuricemia and early-onset gout. Pharmacologic activation of Nrf2 alleviates gout by inhibiting oxidative stress, reducing joint inflammation. Metabolic syndrome is strongly linked to hyperuricemia in both genders, especially in women. Blood metabolites, particularly hexadecanedioate, are found to have a causal link to a reduced risk of gout. Elevated serum uric acid levels and the presence of gout are associated with an increased risk of colorectal cancer. Differences in psoriatic arthritis symptoms are evident between patients with and without hyperuricemia. Endovascular interventional procedures significantly increase the risk of gout flares in the postsurgical period. Utilizing DECT showed that achieving a lower serum urate of <5.0 mg/dL leads to more extensive dissolution of MSU ... Autoimmune hypothyroidism and autoimmune hyperthyroidism have a causal association with an increased risk of gout. A recent study showed that patients with gout, CVD, CKD, and cancer had the highest risk of gout flares. Gout significantly increases the risk of all-cause mortality and mortality due to specific causes. Metformin use was associated with reduced urate levels and a decreased risk of hyperuricemia. Patients with chronic inflammatory diseases face a significantly increased risk of developing post-thrombotic syndrome. Patient characteristics significantly impact serum urate goal achievement during urate-lowering therapy. Examining the potential benefits of pegloticase treatment in patients with CKD with refractory gout. Blood pressure decreased during pegloticase therapy in chronic kidney disease (CKD) and non-CKD patients. There is a significant association between inflammatory bowel disease, particularly Crohn’s disease, and gout. Tophi, as detected by ultrasound, was independently associated with impaired kidney function.