Gender disparities persist in clinical trials related to atrial fibrillation (AF) management. Contemporary films portray cardiac arrest in a misleading fashion. While neuroimaging has advanced with respect to autism/Down syndrome, ADHD still requires standard imaging protocols. An EMR model can enhance postpartum heart screening in women with hypertensive disorders of pregnancy. A study shows geographic disparities that exist as they pertain to heart failure mortality and its association with obesity. GLP1 RA provides a notably superior weight loss option for people with obesity compared with bariatric surgery. A novel study shows a rising trend in cardiac tachyarrhythmia deaths related to obesity. A new study finds a striking increase in obesity prevalence among Black children during the COVID-19 pandemic. Telehealth parity laws notably reduce hospitalization in acute decompensated heart failure. Sudden cardiac death increases amid lower daily temperatures. Acoramidis therapy significantly increases serum transthyretin in people with ATTR-CM compared with tafamidis. Patients with single ventricle heart disease commonly have mental health diagnoses. Acoramidis therapy induces a significant increase in serum transthyretin, which is typically lower in ATTRv-CM. A distributed clinical trial is analyzing diet and exercise patterns in young people with lung cancer. Christopher Seder, MD, discusses the database and how it can be used for research, quality improvement, and risk ... Mara B. Antonoff, MD, FACS, discusses what could be on the horizon for surgery in stage IV lung cancer. Dr. Cytryn summarizes a trial in progress investigating a novel immunotherapy combination for gastroesophageal adenocarcinoma Nivolumab plus ipilimumab provided a higher OS and ORR rate, supporting the combination as a potential standard of care. The combination was shown to provide a 71% response rate, pointing to a new potential treatment for this patient population. With an OS rate of about 80%, encorafenib and cetuximab with FOLFOX may serve as a new FDA-approved frontline regimen.