Imlunestrant plus abemaciclib improved PFS across subgroups in ER+/HER2- breast cancer, per EMBER-3 data. Abemaciclib plus fulvestrant showed benefit across biomarkers after CDK4/6i failure in advanced HR+/HER2- breast cancer. About 40% of patients on AI + palbociclib developed ESR1 mutations in PADA-1, emerging as early as 6 months into treatment. Zanidatamab plus chemo showed promising responses in HER2+ and HER2-low mBC, with durable activity in a phase I trial. Dual immunotherapy plus trastuzumab shows activity in ER+ or PD-L1+ trastuzumab-resistant HER2+ breast cancer. T-DXd improved PFS and response rates vs chemo in HR+/HER2-low or -ultralow metastatic breast cancer in DESTINY-Breast06. Emiltatug ledadotin showed early clinical activity and was well tolerated in heavily pretreated patients with TNBC. Ribociclib plus ET shows similar pCR rates to chemo in intermediate-risk HR+/HER2– early breast cancer, per WSG ADAPTcycle. Gender disparities persist in clinical trials related to atrial fibrillation (AF) management. Contemporary films portray cardiac arrest in a misleading fashion. While neuroimaging has advanced with respect to autism/Down syndrome, ADHD still requires standard imaging protocols. An EMR model can enhance postpartum heart screening in women with hypertensive disorders of pregnancy. A study shows geographic disparities that exist as they pertain to heart failure mortality and its association with obesity. GLP1 RA provides a notably superior weight loss option for people with obesity compared with bariatric surgery. A novel study shows a rising trend in cardiac tachyarrhythmia deaths related to obesity. A new study finds a striking increase in obesity prevalence among Black children during the COVID-19 pandemic. Telehealth parity laws notably reduce hospitalization in acute decompensated heart failure. Sudden cardiac death increases amid lower daily temperatures. Acoramidis therapy significantly increases serum transthyretin in people with ATTR-CM compared with tafamidis. Patients with single ventricle heart disease commonly have mental health diagnoses.