The FDA recently announced a first time proposed rule which would require the tobacco industry to lower nicotine levels. In patients with high-risk HER2-psoitive breast cancer, adjuvant trastuzumab emtansine reduces the long-term risk of death. A new study assessed the link between the cardiometabolic index and the risk of SUI in women. A recent study shows that macrophages can be used to predict whether or not a melanoma patient will respond to chemotherapy. A study shows that humans, mice exposed to long-wavelength red light have lower rates of blood clots that cause stroke. Researchers developed an artificial intelligence algorithm that may improve the diagnosis of REM sleep behavior disorder. A new model called the Florey Dementia Index (FDI) can accurately predict the age at onset of MCI and AD. A groundbreaking study has demonstrated that artificial intelligence can enhance breast cancer detection rates by almost 20%. The CardioNerds and Dr. Mark Drazner discuss the right heart failure device placement with an elderly patient. A recent study found a connection between total serum calcium levels and developing melanoma. An electrocardiography (ECG)–based artificial intelligence risk estimator can predict the development of hypertension. People diagnosed with metastatic breast cancer have a notably increased risk of developing heart disease. Dr. Anne Morse provides a run-down of the important trends, and therapeutic innovations to occur in sleep medicine this year. Dr. Anne Marie Morse provides some gentle reminders for the health implications of over-indulgence during the holidays. A study sought to assess if a treatment combination inhibits tumor growth and metastasis in TNBC. Sacituzumab govitecan-related neutropenia can be effectively treated using G-CSF prophylaxis in patients with mTNBC. A study shows how how advancements in diagnostic tools and treatments for ATTR-CM have improved risk profiles. A recent post-hoc analysis of the ATTRibute-CM trial shows the potential for acoramidis in treating ATTR-CM. A study found an overall decline in surgical myectomy with ICD procedures since 2016. Mobile device-based 3D scanning identifies clinically relevant adolescent idiopathic scoliosis deformity.