This Genetic Variant is Linked to Severe Ulcerative Colitis

Researchers have identified a genetic variant that may help predict the development of severe ulcerative colitis. The study was published in JAMA.

The study, conducted by Aalborg University, assessed both genetic data and Danish health records. The findings showed that found that approximately 3% of patients with ulcerative colitis carry a specific genetic variant, called HLA-DRB1*01:03. Among this group, the researchers noted that over 40% underwent major gastrointestinal surgery within the first three years of diagnosis compared to only 9% of patients without the variant.

“We have long known about this gene and its connection to colitis. However, we have now demonstrated that the same gene can predict whether a patient will require more intensive treatment, including higher medication doses or major surgery. This knowledge is critical as we aim to tailor treatments more effectively,” says PhD student and lead author, Marie Vibeke Vestergaard via a press release. 

Furthermore, Vestergaard stated that: “In cases of ulcerative colitis, early intervention is essential to prevent the disease from progressing and damaging the intestines. Our hope is that this discovery will allow doctors to closely monitor these patients from the very start, potentially administering more aggressive treatment early on.”