DocWire News Editors

DocwireNews

The use of fractional flow reserve (FFR) combined with optical coherence<a href="https://www.docwirenews.com/condition-center/lesion-characteristics-between-cryoballoon-ablation-and-radiofrequency-ablation-with-a-contact-force-sensing-catheter-late-gadolinium-enhancement-magnetic-resonance-imaging-assessment/"> tomography</a> (OCT) improves the accuracy of high-risk lesion identification in diabetic patients, a new study indicates.
Presented at Transcatheter Cardiovascular Therapeutics (TCT 2020), the COMBINE (OCT-FFR) trial was a prospective international natural history study that included 483 patients with stable or acute coronary syndromes and diabetes mellitus who were undergoing angiography who had one or more non-culprit lesions with a 40% to 80% diameter stenosis. Depending on the presence of thin cap fibroatheromas (TCFAs), patients were separated into either TCFA negative (Group A) or TCFA positive (Group B) groups. Those with target lesions with FFR &lt;0.80 were revascularized (Group C). The primary endpoint was the incidence of target lesion-related major adverse cardiovascular events (MACE) defined as cardiac death, target vessel myocardial infarction, clinically-driven target lesion revascularization, or hospitalization with unstable angina at 18 months.
According to the results, the primary endpoint occurred in 13.3% of Group B patients vs. 3.1% of Group A patients (HR=4.7; 95% CI, 2.0 to 10.9; P=0.0004). This suggested that the presence of TCFAs was predictive of future events even in the absence of abnormal FFR. The adverse event rate was higher than the rate of events among revascularized lesions with abnormal FFR at baseline, the authors reported.
“In patients with diabetes, COMBINE (OCT-FFR) showed that the presence of a high-risk plaque (TCFA) is a strong predictor of future MACE, despite lack of ischemia,” said Elvin Kedhi, MD, PhD, a professor of cardiology at Liberal University Brussel Hopital Erasme and Silesian Medical University, in Katowice, Poland, said in a press release about the study. “Additionally, patients with high-risk plaques (TCFAs) have a significant increase in target-lesion related MACE and MI compared to patients without TCFA at 18 months. These findings indicate that combining FFR and OCT can improve the accuracy of high-risk lesion and patient identification and should be adopted in practice.”
Kedhi E. <a href="https://www.tctconnect.com/tct-program-late-breaking-trials-and-clinical-trials/">Outcomes From The North American COVID-19 STEMI Registry</a>. Presented at TCT 2020.

Rob Dillard

Study Finds Link Between Metastatic Breast Cancer and Heart Disease

Breast Cancer News

Zachary Bessette

FDA Approves Nivolumab and Hyaluronidase-nvhy for Subcutaneous Injection

Colorectal Cancer

Cecilia Brown

Dr. Byers Receives 2025 Edith and Peter O’Donnell Award in Medicine for Discoveries in SCLC

Small Cell Lung Cancer

Latest News

COMBINE OCT-FFR: Combined Techniques Improve Plaque Identification in Diabetics

TCT 2020

The use of fractional flow reserve (FFR) combined with optical coherence tomography (OCT) improves the accuracy of high-risk lesion identification in diabetic patients, a new ...

About Us

Editorial Policy

Advertising

eNewsletters

Contribute

Contact Us

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

Mesothelioma

Non-Small Cell Lung Cancer

Squamous Cell Lung Carcinoma

Lung Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

The Oncology Brothers

Rheumatology Rounds With Dr. Maheswaranathan

Healthcare Unfiltered

The Fellow on Call

Partners

Hurricanes & Health Care

Career Center

Expert Interviews

Subscribe