CONUT Score Predicts Prognosis in Patients at High Risk of Cervical Cancer

According to a study, a high preoperative controlling nutritional status (CONUT) score suggests poor prognosis in patients with high-risk factors for early-stage cervical cancer following surgery and concurrent chemoradiotherapy (CCRT). The results were published in the Pakistan Journal of Medical Sciences. 

In this retrospective study, researchers assessed 354 patients, of whom 67.5% were included in the low CONUT score group and 32.5% in the high CONUT score group. The primary end point was defined as overall survival (OS), and the secondary end point was disease-free survival (DFS).

The 3-, 5-, and 10-year OS rates in both groups presented statistically significant differences, the investigators noted. After conducting a multivariate Cox regression analysis, they observed that CONUT score, histological type, perineural invasion, and lymph node metastasis were all independent predictors for OS and DFS.

“High preoperative CONUT score indicates poor prognosis of patients with high-risk factors for early-stage cervical cancer after surgery and postoperative CCRT,” the researchers concluded. “In clinical practice, consolidation chemotherapy is recommended for patients with high CONUT scores.”