Victoria Socha

DocwireNews

<h2>Kidney Week 2020Patients with acute kidney injury commonly experience hyperkalemia. There are few data available on the associated factors and clinical consequences in patients with community-acquired AKI (CA-AKI). Jose M. Pena Porta, MD, and colleagues at Hospital Cl&iacute;nico Universitario Lozano Blesa, Zaragoza, Spain, conducted an study to examine that occurrence. Results of the study were reported in conjunction with ASN Kidney Week in a <a href="https://www.asn-online.org/education/kidneyweek/archives/KW20Abstracts.pdf">poster</a> titled Hyperkalemia in Community-Acquired AKI: Associated Factors and Clinical Consequences.The study cohort included 308 patients with CA-AKI who were admitted to the nephrology service at the clinic from January 2010 to February 2015. The study defined hyperkalemia as potassium level &gt;5.1 mEq/L.Mean age of the cohort was 73.2 years, 58.4% were men, and the mean Charlson comorbidity index (CCI) was 7.16 points. The mean of drugs ingested daily was 7.81 and mean length of stay was 12.25 days. A total of 212 patients had previous chronic kidney disease (68.6%). Of the 308 patients, 54 patients required hemodialysis (17.15%) and 38 died during the hospital stay (12.3%).<a href="https://www.docwirenews.com/nephtimes/nephtimes-diseases-and-conditions/hyperkalemia/hyperkalemia-and-quality-of-life/">Hyperkalemia</a> occurred in 56.2% of the cohort (n=173). Mean potassium level was 5.45 mEq/L. There was a significant correlation between hyperkalemia and pH as well as between potassium and CCI. There were also associations between hyperkalemia and intake of potassium-sparing diuretics (P&lt;.001), angiotensin converting enzyme inhibitors/angiotensin II receptor blockers (P=.003), and beta blockers (P&lt;.001).There was no association between potassium level and length of stay. Patients with hyperkalemia required hemodialysis in a greater proportion compared with patients without hyperkalemia (23.7% vs 9.6%; P=.01), and had higher mortality during the hospital stay (15.6% vs 81.%; P=.048). After follow-up of 971 days following hospital discharge, Kaplan-Meier survival curves showed a significant difference between patients with hyperkalemia and patients without hyperkalemia.&ldquo;Hyperkalemia occurred in just over half of our patients. The potassium level was significantly determined by the previous comorbidity, pH, and the intake of potassium-sparing diuretics. Hyperkalemia patients required hemodialysis and died in a greater proportion during the hospital stay. Mortality after discharge was higher in patients who presented with hyperkalemia. Appropriate measures must be taken to correct hyperkalemia early in patients with CA-AKI,&rdquo; the researchers said.Source: Pena Porta JM, Castellano A, Coscojuela O, et al. Hyperkalemia in community-acquired AKI: Associated factors and clinical consequences. Abstract of a poster published in conjunction with the American Society of Nephrology virtual Kidney Week 2020 (Abstract PUB008).</h2>

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