Mayo Clinic researchers identified a new approach to treating infective endocarditis using a catheter-based method. Results of the EARLY TAVR trial introduced a potential paradigm shift in managing asymptomatic high-gradient severe AS. Two pivotal trials—EARLY TAVR and EVOLVED—were presented, each exploring early intervention in asymptomatic severe AS. ECLIPSE investigated whether OA provides better outcomes than conventional balloon angioplasty in calcified coronary lesions. An analysis of PROTECTED TAVR trial highlighted potential regional differences in the efficacy of CEP during TAVR. Sirolimus-coated balloons are non-inferior to paclitaxel-coated balloons in patients with femoropopliteal artery disease.