Proinflammatory Biomarkers in Patients With ADPKD

Inflammation and fibrosis play an important role in the pathogenesis of autosomal polycystic kidney disease (ADPKD). Inflammatory markers associated with the development and progression of ADPKD have been identified, including monocyte chemoattractant protein-1 (MCP-1) and TNF-α. Sita Arjune, PhD, and colleagues conducted an exploratory pilot study to identify and evaluate potential proinflammatory biomarkers in patients with ADPKD from the German AD(H)PKD registry. 

The researchers used multiplex immunoassay to measure serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-10, IL-13, IFN-γ, MCP-1, and TNF-α in adults with ADPKD from the registry (n=233). These patients were compared to an age- and sex-matched healthy control group (n=30). 

The study found that IL-6, IL-8, MCP-1, TNF-α, and IFN-γ concentrations were significantly higher in patients with ADPKD compared to the healthy controls. Patient sex affected the concentrations of MCP-1 and TNF-α in both the ADPKD and control groups (MCP-1 male=134.8 pg/L, female=75.11 pg/L; P=.0055; TNF-α male=26.22 pg/L, female=21.08 pg/L; P=.0038). 

The findings indicate that inflammation may have a critical role in the pathogenesis of ADPKD and could potentially serve as a target for biomarkers and therapeutic interventions. 

Source: Kidney360.