Victoria Socha

DocwireNews

Patients with autosomal dominant polycystic kidney disease (ADPKD) commonly progress to end-stage renal disease (kidney failure) in the fifth decade of life. According to researchers, led by Alan S L Yu, there is a significant unmet need for an accurate prognostic model that can predict the course of ADPKD early in individual patients.
CRISP IV is the longest existing ADPKD cohort (21 years), providing an opportunity to identify the association between clinical observations early in the disease and hard clinical outcomes. Data were collected from participants in the CRISP and HALT-A studies between 2001 and 2022. Multivariable Cox proportional hazards models were used in data analysis.
The outcome of interest was a composite of kidney failure, defined as the need for dialysis or kidney transplant, and estimated glomerular filtration rate &lt;15 mL/min/1.73 m2. Candidate dependent variables were selected on the basis of face validity, and included in the model via iterative forward selection.
The analysis included data on 759 participants. Median follow-up was 8.2 years. During follow-up, 16.2% of the cohort (n=123) reached the composite endpoint. A prognostic model was built using five essential variables. Four clinical variables were found to add independently to the model: serum CO2, hemoglobin, body mass index, and diastolic blood pressure.
“We have developed a prognostic model that can predict kidney failure in an ADPKD patient over a time horizon of 15 years,” the researchers said. “The next step is to validate this in an external ADPKD registry cohort and create a risk calculator.”
Source: Yu ASL, Cohen A, Ables E, et al. Prognostic model for progression of autosomal dominant polycystic kidney disease to kidney failure. <a href="https://www.asn-online.org/education/kidneyweek/2023/program-abstract.aspx?controlId=3942983" target="_blank" rel="noopener">TH-PO427</a>. Abstract of a poster presented at the American Society of Nephrology Kidney Week 2023; November 2, 2023; Philadelphia, Pennsylvania.

Emily Menendez

SBRT Plus Sorafenib Boosts OS Over Sorafenib Alone for HCC

Hepatocellular Carcinoma

Laura Litwin

Study Highlights Importance of Pretreatment Frailty Assessments for Older Adults With Advanced NSCLC

Non-Small Cell Lung Cancer

Adewole Adamson, MD

How the Increasing Incidence of Pancreatic Cancer is Linked to Early-Stage Endocrine Cancer

Pancreatic Cancer

Latest News

Predicting Progression to Kidney Failure in Patients With ADPKD

ADPKD

There is a significant unmet need for an accurate prognostic model that can predict the course of ADPKD early in individual patients.

About Us

Editorial Policy

Advertising

eNewsletters

Contribute

Contact Us

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

Mesothelioma

Small Cell Lung Cancer

Squamous Cell Lung Carcinoma

Lung Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

The Oncology Brothers

Rheumatology Rounds With Dr. Maheswaranathan

Healthcare Unfiltered

The Fellow on Call

Partners

Hurricanes & Health Care

Career Center

Expert Interviews

Subscribe