New Real-World Data on MACEs in Ulcerative Colitis

A study published in Journal of Gastroenterology Hepatology aimed to identify incidence rates and potential risk factors of major adverse cardiac events (MACEs) in Japanese patients with ulcerative colitis (UC). The researchers conducted a retrospective study to fill in gaps of the scarce existing data and aimed to provide a limited representation of real-world data on MACEs in Japan.

The researchers used administrative claims data collected between January 2013 and December 2022 from Medical Data Vision in Japan. Patients included in the incidence cohort (N=11,407) were aged 20 years or older and were diagnosed with UC within ± one month of the prescription date during the study period. Exclusion criteria included myocardial infarction, heart failure, stroke, or other ischemic heart diseases within 30 days pre-index.

Cumulative MACE incidence rate was calculated using the Kaplan-Meier method; multivariate Cox regression models were used to calculate hazard ratios (HRs) for all relevant potential risk factors.

Of the patients in the incidence cohort, 91 (0.8%) experienced incident MACE. Over 120 months, the cumulative incidence rate of MACEs was 2.86% (95% CI, 1.89-4.32). Significant HRs were found for age category (≥ 65 years; HR, 4.557; 95% CI, 2.786-7.452), diabetes (HR, 1.709; 95% CI, 1.030-2.835), and atrial fibrillation (HR, 2.759; 95% CI, 1.188-6.405), with all P<.05.

Patients with a history of stroke showed numerically increased risk (HR, 1.871; 95% CI, 0.508-6.886) of MACEs. Sensitivity analyses with a broader definition of MACE showed a MACE incidence rate of 4.69% (95% CI, 2.13-10.17) over follow-up of 120 months.

“The cumulative incidence rate of MACE was 2.86% over 120 months. Age, comorbidities of diabetes and [atrial fibrillation], and history of stroke were the major risk factors for MACE in Japanese UC patients,” the researchers concluded.

Source

Journal of Gastroenterology Hepatology