The PRAECIS Trial, Predicting Severe Preeclampsia

Nothing terrifies nephrologists quite like the consult from labor and delivery. And one of the most vexing questions is, “Is this preeclampsia, proteinuric CKD, or a lupus flare?”

Perhaps a newly approved blood test will be able to shed light on this clinical conundrum. The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) has appeared predictive of severe preeclampsia. The PRAECIS trial evaluated this in a prospective manner.