In this episode of The Fellow on Call: The Heme/Onc Podcast, the group continues their series on emergencies in hematology and oncology. How do you diagnose thrombotic thrombocytopenic purpura (TTP)? The group points out clinical presentations including fever, anemia, acute kidney injury, as well as a diminished mental state, and noted that if you see these manifestations, the patient is in bad shape. They also characterize the mechanism of TTP (the formation of tiny blood clots, resulting in platelet forming), and how to optimally manage and treat the blood disorder.