Immunotherapy in Non-Small Cell Lung Cancer
It is the "first and only neoadjuvant-only immuno-oncology therapy" to show a significant OS benefit in this setting.
The study is comparing ivonescimab plus platinum-based chemotherapy with tislelizumab plus platinum-based chemotherapy.
The study aims to confirm safety and efficacy findings from the phase 2 QUILT 3.055 trial.
Despite decades of decline, "lung cancer continues to dwarf other cancers in the number of deaths," officials said.
The therapy is now the “first and only subcutaneously administered PD-1 inhibitor," officials said in an announcement.
The foundation's 2024 Scientific Grant Program awards mark the "largest single-year investment in its history.”
The new study is working to identify additional therapeutic combinations targeted towards patients with NSCLC and low PD-L1.
Patients with NSCLC, treated with an immunotherapy regimen, have a higher risk of pneumonitis with decreased lung volume.
An analysis of the CCTG BR.34 trial showed that bone metastasis correlated with worse outcomes in patients with NSCLC.
Detailed data from the trial will be presented at a medical meeting in 2025.
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