Immunotherapy in NSCLC
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It is the "first and only neoadjuvant-only immuno-oncology therapy" to show a significant OS benefit in this setting.
The study is comparing ivonescimab plus platinum-based chemotherapy with tislelizumab plus platinum-based chemotherapy.
The study aims to confirm safety and efficacy findings from the phase 2 QUILT 3.055 trial.
Despite decades of decline, "lung cancer continues to dwarf other cancers in the number of deaths," officials said.
The therapy is now the “first and only subcutaneously administered PD-1 inhibitor," officials said in an announcement.
The foundation's 2024 Scientific Grant Program awards mark the "largest single-year investment in its history.”
The new study is working to identify additional therapeutic combinations targeted towards patients with NSCLC and low PD-L1.
Patients with NSCLC, treated with an immunotherapy regimen, have a higher risk of pneumonitis with decreased lung volume.
An analysis of the CCTG BR.34 trial showed that bone metastasis correlated with worse outcomes in patients with NSCLC.
Detailed data from the trial will be presented at a medical meeting in 2025.
Researchers Analyze Olaparib, Pemetrexed as Maintenance Therapy Additions to Pembrolizumab for NSCLC
Pembrolizumab plus maintenance olaparib was not shown to improve survival in patients with metastatic nonsquamous NSCLC.
Durvalumab does not improve overall survival compared to chemotherapy when used as a first-line treatment for mNSCLC.
For patients with inoperable stage III NSCLC, ctDNA is associated with survival outcomes of consolidation immunotherapy.
The study is evaluating the combination as an adjuvant treatment for certain patients with resectable NSCLC.
Researchers conducted an analysis of CheckMate 227 and CheckMate 9LA studies to evaluate pooled patient outcomes.
Gene Ho, MPH, discusses real-world data on adverse events and survival outcomes with immunotherapy for NSCLC.
The CheckMate 77T trial evaluated the efficacy of adjuvant and neoadjuvant nivolumab in resectable, untreated NSCLC.
The trial is investigating nogapendekin alfa inbakicept-pmln in combination with immune checkpoint inhibitor therapy.
The trial is evaluating perioperative pembrolizumab plus sacituzumab govitecan for certain patients with NSCLC.
The subcutaneous injection is now approved for all adult indications of the intravenous formulation of atezolizumab
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