In a phase 2 study, adding tivozanib to nivolumab did not show a benefit for renal cell carcinoma treatment. The FDA granted Fast Track designation to ADI-270 for treating metastatic or advanced clear cell renal cell carcinoma. What does the data and overall understanding of VEGF-TKIs tell us about which patients are optimal candidates for tivozanib? Treatment for advanced renal cell carcinoma (aRCC) commonly includes immune-oncology therapies and tyrosine kinase ... The U.S. Food and Drug Administration approved pembrolizumab (Keytruda®) in combination with axitinib (Inlyta®) for ...