Data on growing pancreatic cancer cases in young Americans shows that some cases are misattributed as early endocrine cancer. Dr. Joseph Cullen discusses the combination of vitamin C with gemcitabine and nab-paclitaxel for pancreatic cancer. Dr. Cytryn provides insights on the FDA approval of zolbetuximab and how it will impact clinical practice. Dr. Richard Finn provides an overview of the key studies in liver cancer from ESMO 2024. HIMALAYA found tremelimumab plus durvalumab to significantly improve overall survival over sorafenib alone. Dr. Wungki Park gives an overview of the POLAR study for metastatic pancreatic cancer. Dr. Wungki Park of Memorial Sloan Kettering Cancer Center discusses his trial on the use of ASP3082 for solid tumors. Dr. Leong showcases the highly anticipated results of the TOPGEAR study in patients with resectable G/GEJ adenocarcinoma. Dr. Wainberg reviews the data on GI malignancies and notes that it is unclear who should receive radiation before surgery. Dr. Josep Llovet discusses promising data, including higher PFS and OS, in metastatic liver cancer from the LEAP-012 trial. Dr. Janjigian shares an overview of the DESTINY-Gastric03 study and the history of T-Dxd for gastric and GEJ cancers. Dr. Grady opines on whether colonoscopy, stool-based, or blood-based tests will be integrated into CRC screening guidelines. Dr. Grady discusses ECLIPSE for colorectal cancer screening and the findings that led to approval of the Shield test. Dr. Lieu breaks down his top uses of AI in GI oncology today, as well as their projected applicability in the near future. Dr. Amit Mahipal discusses a recent study on atezolizumab plus bevacizumab as a first-line treatment for HCC. Dr. Dan Kaufman discusses recent research on TGF-β and how it is linked to the development of HCC. Dr. El-Deiry expands on reducing ALDH1 expression in HT29 cells, and the benefits of targeting ERK1/2 and STAT3 activation. Dr. Wafik El-Deiry of Brown University discusses his study on regorafenib with TAS-102 for colorectal cancer. Dr. Joel Rubenstein discusses the recent American Gastroenterological Association guideline on EET for Barrett's esophagus. Dr. Cecchini explains how ctDNA was used in this study as well as which methods were used for analyzing ctDNA levels.