NEST-1: Neoadjuvant Botensilimab, Balstilimab for pMMR/MSS Colorectal Cancer

By Pashtoon Kasi, MD, MS - Last Updated: March 19, 2025

Pashtoon Kasi, MD, MS, Weill Cornell Medicine, showcases the NEST-1 clinical trial, an early-stage investigation into neoadjuvant botensilimab plus balstilimab in resectable mismatch repair proficient and deficient colorectal cancer.

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Dr. Kasi expounds on what the latest data shows regarding adverse events and downstaging as a result of this regimen.

View Dr. Kasi’s other comments on BESPOKE CRC: ctDNA for Informing Adjuvant Chemotherapy in Colorectal Cancer.

All images and data were presented at the 2024 American Society of Clinical Oncology® Gastrointestinal Cancer Symposium.

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