Histotripsy is an innovative modality for treating liver tumors that offers several advantages. The number of arteries treated during transarterial chemoembolization did not affect outcomes in liver cancer patients. Radiation lobectomy with transarterial embolization of Yttrium-90 is a viable option for hepatocellular carcinoma. Durvalumab plus tremelimumab significantly improved overall survival in patients with unresectable liver cancer.