Rob Dillard

DocwireNews

Breast cancer survivors have an increased risk of type 2 diabetes (T2D), according to a study being presented at ESMO Breast Cancer 2024, taking place May 15-17 in Berlin, Germany.
&#8220;Contemporary data on the risk of T2D after breast cancer are needed to guide preventive management, especially according to the type of adjuvant cancer therapy,&#8221; the researchers noted.
They used Danish medical registries to establish a nationwide population-based cohort of 74,526 breast cancer survivors and 372,630 matched comparisons. All subjects were 30 years of age and older. Patients in the population of interest were followed until a diagnosis of T2D, emigration, death, or December 31, 2022, whichever occurred first.
<h2>Breast Cancer Therapy Linked to T2D?</h2>
The results showed that adjuvant endocrine therapy (adjusted hazard ratio [aHR], 1.14; 95% CI, 1.10-1.19), particularly aromatase inhibitor treatment (aHR, 1.25; 95%CI, 1.18-1.32) and, to a lesser extent, tamoxifen (aHR, 1.05; 95% CI, 0.99-1.11) were correlated with a higher risk of T2D in women with breast cancer compared with matched breast cancer-free women. Notably, breast cancer survivors who did not receive endocrine therapy did not have an increased risk of T2D compared with matched breast cancer-free women. In the breast cancer cohort, the researchers observed that any chemotherapy (aHR, 1.10; 95%CI, 1.03-1.17) and radiation therapy (right-sided aHR, 1.18; 95%CI, 1.09-1.27 and left-sided aHR, 1.24; 95% CI, 1.15-1.33) were also associated with increased risk of T2D.
&#8220;Breast cancer survivors had a modestly increased risk of T2D compared with women without breast cancer. The excess T2D risk seems to be largely driven by breast cancer therapy modalities,&#8221; the researchers concluded.

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Do Breast Cancer Survivors Have a Greater Risk of Type 2 Diabetes?

ESMO Breast Cancer 2024

Breast cancer survivors have a modestly increased risk of type 2 diabetes, largely driven by breast cancer treatment modalities.

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